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Treating Prurigo Nodularis

Prurigo Nodularis Medications

There is currently one FDA approved therapy, dupilumab, which is an IL-4 Receptor alpha inhibitor and reduces itch, skin lesions, and sleep disturbance. Phototherapy may also be used to reduce itch.

Nonspecific itch-reducing household products or medications
  • Calamine lotion
  • Camphor
  • Diphenhydramine (Benadryl)
Topical corticosteroids to reduce inflammation
  • Clobetasol 0.05%
  • Betamethasone 0.1%
Topical calcineurin inhibitors to reduce itch
  • Pimecrolimus 1% cream
  • Tacrolimus 0.1% ointment
Neurologic medications to reduce itch
  • Amitriptyline
  • Pregabalin
  • Naltrexone
Oral immunosuppressants to reduce inflammation
  • Cyclosporine
  • Methotrexate
  • Thalidomide